Aptamers: Biomedical Interest and Applications
نویسندگان
چکیده
منابع مشابه
Aptamers: Biomedical Interest and Applications
Aptamers are short DNA or RNA oligonucleotides specialized in the specific and efficient binding to a target molecule. They are obtained by in vitro selection or evolution processes. It was in 1990 that two independent research groups described the bases of a new in vitro technology for the identification of RNA molecules able to specifically bind to a target [1,2]. Tuerk and Gold established t...
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Nucleic acid aptamers are moving towards genuine competitiveness in therapeutic, diagnostic and biomaterials applications. We have introduced a major new aptamer class multivalent circular aptamers or ‘captamers’ that combines aptameric recognition with multitasking nucleic acid functions through the use of modular engineering principles derived from DNA nanotechnology. DNA captamers have been ...
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aptamers define a new interesting class of receptor molecules with capability of binding to potentially any kind of molecules of interest. structurally, they are composed of nucleic acids (rna, dna or a mixture of both) with high specificity and affinity to amino acids, drugs, proteins and other molecules. apatmers are isolated from complex libraries of synthetic nucleic acids against the desir...
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Recently, aptamers have attracted the attention of many scientists, because they not only have all of the advantages of antibodies, but also have unique merits, such as thermal stability, low cost, and unlimited applications. In this review, we present the reasons why aptamers are known as alternatives to antibodies. Furthermore, several types of in vitro selection processes, including nitrocel...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2017
ISSN: 1424-8247
DOI: 10.3390/ph10010032